Thioredoxins are small enzymes that participate in redox reactions via the reversible oxidation of an active center disulfide bond [1]. They serve as general protein disulfide oxidoreductases and interact with a broad range of proteins. Protein disulfide isomerases contain two active redox domains similar to thioredoxins. Redoxins (AllFam:AF131) are redox enzymes closely-related to thioredoxin.
Allergenic thioredoxins are found in fungi as well as in plants. The fungal allergens Asp f 28 and Asp f 29 from Aspergillus fumigatus and Mala s 13 from Malassezia sympodialis are thioredoxins, while Alt a 4 from Alternaria alternata is a protein disulfide isomerase [2]. Allergenic thioredoxins from plants include cereal allergens associated with baker's asthma [3].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00085 | Thioredoxin | CL0172 | Thioredoxin-like |
| PF13848 | Thioredoxin-like domain | CL0172 | Thioredoxin-like |
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