A number of eukaryotic extracellular proteins have been shown to be evolutionarily related. The family includes rodent sperm-coating glycoprotein, which is thought to be involved in sperm maturation, mammalian testis-specific protein (Tpx-1), mammalian cysteine rich secretory proteins (CRISP), glioma pathogenesis-related protein, reptile toxins, group 5 insect venom allergens, and plant pathogenesis-related proteins PR-1. The name "CAP familiy" derives from Cysteine rich secretory protein, Antigen 5 and Pathogenesis-related protein PR-1. Members of this family, albeit highly diverse, contain a conserved calcium-binding site [1].
Most allergens from this family are insect venom allergens including group 5 wasp allergens and group 3 ant allergens [2]. Allergens from the plant PR-1 family include the Bermuda grass pollen allergen Cyn d 24, the mugwot pollen allergen Art v 2 and the muskmelon allergen, Cuc m 3.
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00188 | Cysteine-rich secretory protein family | - | |
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