Calreticulin is a high-capacity calcium-binding protein which is present in most tissues and located at the periphery of the endoplasmic (ER) and the sarcoplamic reticulum (SR) membranes. It plays a role in the storage of calcium in the lumen of the ER and SR and is also an important molecular chaperone involved in quality control within secretory pathways [1]. This family also includes calnexin and camlegin.
The Penicillium chrysogenum allergen Pen ch 31 is a calreticulin.
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00262 | Calreticulin family | - | |
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