Glycoside hydrolase family 28 comprises enzymes with polygalacturonase, exo-polygalacturonase, or rhamnogalacturonase activity. Polygalacturonase (pectinase) catalyzes the random hydrolysis of 1,4-α-D-galactosiduronic linkages in pectate and other galacturonans. In fruits, polygalacturonase plays an important role in cell wall metabolism during ripening [1]. In plant pathogens, polygalacturonase is involved in maceration and soft-rotting of plant tissue.
Polygalacturonases are major pollen allergens in Cupressaceae trees (group 2 allergens) [2]. In addition, they were identified in grass pollen (group 13) [3] and in plane tree pollen (Pla a 2). Polygalacturonases contain N-linked glycans, which take part in IgE binding [4].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00295 | Glycosyl hydrolases family 28 | CL0268 | Pectate lyase-like beta helix |
Additional Pfam domains found in some family members:
| Pfam domain | Pfam clan | ||
| PF17181 | Epidermal patterning factor proteins | - | |
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