The histidine phosphatase superfamily derives its name from a conserved His residue in the catalytic center that is transiently phosphorylated during the catalytic cycle [1]. The superfamily is divided into two main branches. The smaller branch 2 contains predominantly eukaryotic proteins. Their functions include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatases.
The major honeybee allergen Ap m 3 and Asp n 25, a phytase from Aspergillus niger, belong to this family [2, 3].
Family-defining Pfam domains (at least one of these domains is present in each family member):
Pfam domain | Pfam clan | ||
PF00328 | Histidine phosphatase superfamily (branch 2) | CL0071 | Histidine phosphatase superfamily |
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