Melittin is the principal protein component of the venom of the honeybee, Apis mellifera. It inhibits protein kinase C, Ca2+-calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase and is a cell membrane lytic factor [1]. Melittin is a small peptide with no disulphide bridge.
Melittin (Api m 4) is a minor honeybee venom allergen [2].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF01372 | Melittin | - | |
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