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AF201: Actin-depolymerising factor homolog
Biochemical properties
This family defines an approximately 150 amino acid motif that is present in three phylogenetically distinct classes of eukaryotic actin-binding proteins [1]:
- Actin depolymerising factors/cofilins are small actin-binding proteins composed of a single ADF-H domain. They bind both actin-monomers and filaments and promote rapid filament turnover.
- Twinfilins, which are actin monomer-binding proteins that are composed of two ADF-H domains.
- Abp1/Drebrins, which are composed of an N-terminal ADF-H domain followed by a variable region and a C-terminal SH3 domain. Abp1/Drebrins interact only with actin filaments and do not promote filament depolymerisation or fragmentation.
Allergens from this family
A cofilin from house dust mite, Der f 31, was identified as a minor allergen.
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References
- Lappalainen P, Kessels MM, Cope MJ, Drubin DG:
The ADF homology (ADF-H) domain: a highly exploited actin-binding module.
Mol Biol Cell 1998, 9, 1951-9. [PubMed]
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Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain |
Pfam clan |
|
PF00241
|
Cofilin/tropomyosin-type actin-binding protein
|
CL0092
|
Actin depolymerizing Factor
|
Links to Wikipedia
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