This entry represents both eukaryotic mitochondrial porins and Tom40 proteins [1]. Mitochondrial porins are voltage-dependent anion-selective channels that behave as general diffusion pores for small hydrophilic molecules. They are beta-barrel proteins, composed of between 12 to 16 beta-strands that span the mitochondrial outer membrane. Tom40 is a mitochondrial outer membrane protein and a component of the TOM (translocator of the outer mitochondrial membrane) complex, which is essential for import of protein precursors into mitochondria.
Aed a 6, an allergen from the yellow fever mosquito, belongs to this family.
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF01459 | Eukaryotic porin | CL0193 | Outer membrane beta-barrel protein superfamily |
If you have updates or corrections for this entry, please contact the site administrator: christian.radauer@meduniwien.ac.at .
