AF208: Nematode polyprotein ABA-1

List allergens from this family:

Sources:
Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Nematode polyprotein allergens are lipid-binding proteins specific to nematodes. They are synthesized as large, tandemly repetitive polyproteins that are post-translationally cleaved into multiple copies of small lipid binding proteins with virtually identical fatty acid and retinol-binding characteristics. They are probably central to transport and distribution of small hydrophobic compounds between the tissues, and may play key roles in nutrient scavenging and immunomodulation. The proteins adopt a novel seven-helical fold comprising a long central helix that participates in two hollow four-helical bundles on either side [1].

Allergens from this family

ABA-1 proteins are important IgE-binding antigens of parasitic nematodes [2].

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References

  1. Meenan NA, Ball G, Bromek K, Uhrin D, Cooper A, Kennedy MW, Smith BO:
    Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of Ascaris reveals a novel fold and two discrete lipid-binding sites.
    PLoS Negl Trop Dis 2011, 5, e1040. [PubMed] [Full Text]
  2. Christie JF, Dunbar B, Davidson I, Kennedy MW:
    N-terminal amino acid sequence identity between a major allergen of Ascaris lumbricoides and Ascaris suum, and MHC-restricted IgE responses to it.
    Immunology 1990, 69, 596-602. [PubMed]

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Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF16469 Nematode polyprotein allergen ABA-1 -

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