TABLES
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FIGURES
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Table 1
Demographic data of patients comparing the different CADI groups. |
Figure 1
Distribution of histological parameters. ati ... acute tubular injury; ta ... tubular atrophy; ii ... interstitial inflammation; if ... interstitial fibrosis; as ... arteriolosclerosis; gs ... glomerulosclerosis |
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Table 2
Significantly enriched biological processes in upregulated DEGs are provided for the six histological parameters. The number in parenthesis depicts the number of DEGs that could be assigned to at least one category in the respective group. The number of genes for each category and histological parameter is provided where significantly enriched categories are indicated with an asterisk. |
Supplementary figure 1
Number of differentially expressed genes (DEGs) between damaged and healthy tissue. The Venn diagram shows the overlap of identified DEGs when comparing damaged versus healthy tissue based on the six histological parameters. Two genes, namely IGJ and CD52 were upregulated in damaged tissue samples no matter which histological parameter was investigated. |
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Table 3
Linear regression model of histological and clinical parameters to predict creatinine values of one year after engraftment. |
Supplementary figure 2
Interaction network of DEGs and interacting proteins. DEGs are represented as grey filled nodes whereas interacting proteins connecting at least two DEGs are represented as smaller white nodes. Node border colors of DEGs depict the cluster assignment based on gene expression patterns. Node size of DEGs corresponds to the number of significant findings associated with the six histological parameters. |
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Table 4
Linear regression using molecular biomarkers to predict creatinine values of one year after engraftment. |
Supplementary figure 3
Scatterplot of predicted creatinine values to measured creatinine values after leave-one-out cross validation. The Pearson correlation coefficient between predicted and measured creatinine values was 0.45. |
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Supplementary table 1
Linear regression model of histological parameters represented as the CADI score to predict creatinine values of one year after engraftment. |
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Supplementary table 2
Model selection process with the seven molecular markers as independent variables to predict creatinine values one year after engraftment. |
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Supplementary table 3
Linear regression using molecular biomarkers in combination with clinical parameters to predict creatinine values of one year after engraftment. |
Original data according to MIAME-Guidelines
MIAME.pdf
Data of all arrays in a single rar-File: Arraydata.rar (6.6 MB)