ACE-Inhibitor or AT2-Antagonist therapy of renal transplant recipients is associated with an increase in serum potassium concentrations.

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C. Mitterbauer(1), G. Heinze(2), A. Kainz(1,3), W.H. Hörl(1), R. Oberbauer(1,3)

1- Department of Nephrology, Medical University of Vienna, Austria

2- Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Austria

3- Department of Nephrology, KH Elisabethinen, Linz, Austria

 

// Tables
// Figures

Webtable1:
Webtable1:

Assessment of working correlation structure.

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Webfigure 1:
Webfigure 1:

Boxplot of potassium levels vs. year after engraftment, stratified for ACEI/ARB use.

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Webtable 2:
Webtable 2:

Mixed linaer model with “sticky” group definition

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Webfigure 2:
Webfigure 2:

Number of ACEI/ARB user/nonusers vs. year after engraftment.

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Webtable 3:
Webtable 3:

Testing for interaction between ACEI/ARB and year of use (sticky group definition)

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Webfigure 3:
Webfigure 3:

Percentage of ACEI/ARB user/nonuser vs. year after engraftment.

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Webtable 4:
Webtable 4:

Mixed linaer model without ACEI/ARB changers.
Subjects who switched groups were eliminated as suggested by the reviewer. The results are materially identical to the other models presented above and in the manuscript in table 3.

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Webfigure 4:
Webfigure 4:

Residual diagnostics

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Webtable 5:
Webtable 5:

Test for interaction of ACEI/ARB and CNI use.

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Webfigure 5ab:
Webfigure 5ab:

a,b: Residuals against predicted values

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Webfigure 5cd:
Webfigure 5cd:

c,d: Absolute residuals against predicted values (to detect heteroscedasticity)

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