Statin use is associated with prolonged survival of renal transplant recipients.

F. Wiesbauer(1)*, G. Heinze(2)*, C. Mitterbauer(3), F. Harnoncourt(4), WH. Hörl(3), R. Oberbauer(3,4,5)

1- Department of Cardiology, Medical University of Vienna, Austria

2- Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Austria

3- Department of Nephrology, Medical University of Vienna, Austria

4- Department of Nephrology, KH Elisabethinen, Linz, Austria

5- Austrian Dialysis and Transplant Registry, Wels, Austria

* Both authors contributed equally to the paper

 

// Tables
// Figures

Webtable 1:
Webtable 1:

Characteristics of all 1,829 patients with graft survival of at least 90 days

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Webfigure 1:
Webfigure 1:

Hazard function (risk for graft loss or death per year)

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Webtable 2:
Webtable 2:

Complete Case Only analysis

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Webfigure 2:
Webfigure 2:

Cardiovascular death outcome
Among the 2041 patients, 223 died with confirmed cardiovascular causes. 35 of these 223 deaths occurred before day 90. Extended Kaplan-Meier plot stratified for (timedependent) statin

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Webtable 3:
Webtable 3:

Analysis of sensitivity of multiple imputation approach (comparison of results from multiple imputation after randomly deleting data and non-randomly deleting data)

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Webfigure 3a:
Webfigure 3a:

Analysis including events between days 0 and 90
Kaplan-Meier analysis

a Patient survival

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Webfigure 3b:
Webfigure 3b:

Analysis including events between days 0 and 90
Kaplan-Meier analysis

b actual graft survival

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Webfigure 3c:
Webfigure 3c:

Analysis including events between days 0 and 90
Kaplan-Meier analysis

c functional graft survival

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Webtable 4a:
Webtable 4a:

Analysis repeated without cholesterol

a Patient survival

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Webtable 4b:
Webtable 4b:

Analysis repeated without cholesterol

b actual graft survival

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Webtable 4c:
Webtable 4c:

Analysis repeated without cholesterol

c functional graft survival

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Webtable 5:
Webtable 5:

MSM analysis without statin users at baseline

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Webtable 6:
Webtable 6:

Clinical expertise models (HLA mismatches, CIT, Induction therapy, donor age forced into model)

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Webtable 7a:
Webtable 7a:

Interaction analysis (HR of statin use in subgroups which were close to significant)

a Patient survival

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Webtable 7b:
Webtable 7b:

Interaction analysis (HR of statin use in subgroups which were close to significant)

b actual graft survival

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Webtable 7c:
Webtable 7c:

Interaction analysis (HR of statin use in subgroups which were close to significant)

c functional graft survival

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Webtable 8a:
Webtable 8a:

Assessment of proportional hazards assumption of statin use

a Patient survival

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Webfigure 8a:
Webfigure 8a:

Schönfeld residuals

a Patient survival

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Webtable 8b:
Webtable 8b:

Assessment of proportional hazards assumption of statin use

b actual graft survival

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Webfigure 8b:
Webfigure 8b:

Schönfeld residuals

b actual graft survival

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Webtable 8c:
Webtable 8c:

Assessment of proportional hazards assumption of statin use

c functional graft survival

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Webfigure 8c:
Webfigure 8c:

Schönfeld residuals

c functional graft survival

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Webtable 9:
Webtable 9:

Analysis of time to (biopsy confirmed) acute rejection
Results from Kaplan-Meier analysis and Cox regression. Dependent variable: BCAR up to one year after transplantation.

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Webtable 10:
Webtable 10:

Multivariable Cox’s proportional hazards model assessing the confounder-adjusted association of statin treatment on actual graft survival (graft failure and death with functioning graft counted as endpoints)

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Webfigure 10:
Webfigure 10:

Kaplan-Meier curves of actual graft survival

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Webtable 11:
Webtable 11:

Multivariable Cox analysis assessing the effect of statin treatment on patient survival and functional graft survival.

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Webfigure 11:
Webfigure 11:

Onset of statin treatment after transplantation.

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SCIENTIFIC COLLABORATIONS